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| Artikel-Nr.: 5667A-9783038424307 Herst.-Nr.: 9783038424307 EAN/GTIN: 9783038424307 |
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| Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication. Weitere Informationen: | | Author: | Barth Holger | Verlag: | MDPI | Sprache: | eng |
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| Weitere Suchbegriffe: Bacterial AB-toxins; cellular uptake; intracellular transport, binary clostridial actin ADP-ribosylating toxins, Diphtheria toxin, intracellular transport, Bacterial AB-toxins, Clostridium difficile toxins, pore-forming toxins, pore-blockers, membrane transport, clostridial toxins, Shiga toxin |
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