Biochemical and Clinical Aspects of Pteridines. Cancer - Immunology - Metabolic Diseases / February 23-March 2, 1985, St. Christoph, Arlberg, Austria

Frontmatter -- PREFACE -- LIST OF PARTICIPANTS -- CONTENTS -- 1. CHEMISTRY AND ANALYSIS OF PTERIDINES -- ELECTROLYSIS OF PTERIDINES / Pfleiderer, Wolfgang / Gottlieb, Raphael -- NITRITE OXIDATION OF TETRAHYDROPTERINS / Heales, S.J.R. / Blair, J.A. / Guest, A.E. / Pheasant, A.E. -- ACYLATION OF TETRAHYDROPTERINS / Lockhart, Ronan John / Pfleiderer, Wolfgang -- SYNTHESIS AND PROPERTIES OF 5,6-DIHYDROPTERIDINES / Soyka, Rainer / Pfleiderer, Wolfgang -- SYNTHESIS AND PROPERTIES OF NEW TETRAHYDROPTERIDINES / Traub, Hermann / Pfleiderer, Wolfgang -- INTER- AND INTRAMOLECULAR REDOX-REACTIONS BY 5,6- RESP. 7,8-DIHYDROPTERINES; DO THESE COMPOUNDS BEHAVE AS REDOX COFACTORS DURING THE BIOSYNTHESIS OF 5,6,7,8-TETRAHYDRO-L-BIOPTERIN ? / Viscontini, Max -- DETERMINATION OF NEOPTERIN AND REDUCED NEOPTERINS BY RADIOIMMUNOASSAY / Rokos, H. / Bienhaus, G. / Gadow, A. / Rokos, K. -- THE DETERMINATION OF PTERINS, BIOGENIC AMINE METABOLITES, AND AROMATIC AMINO ACIDS IN CEREBROSPINAL FLUID USING ISOCRATIC REVERSE PHASE LIQUID CHROMATOGRAPHY WITH IN SERIES DUAL CELL COULOMETRIC ELECTROCHEMICAL AND FLUORESCENCE DETECTION:- USE IN THE STUDY OF INBORN ERRORS OF DIHYDROPTERIDINE REDUCTASE AND 5,lO-METHYLENETETRAHYDROFOLATE REDUCTASE / Hyland, K. / Smith, I. / Howells, D. W. / Clayton, P. T. / Leonard, J. V. -- 2. BIOCHEMISTRY AND METABOLISM OF PTERIDINES -- TETRAHYDROBIOPTERIN METABOLISM IN THE CENTRAL NERVOUS SYSTEM / Blair, John A. -- ENZYMATIC FORMATION OF H4-BIOPTERIN IN DROSOPHILA MELANOGASTER / Brown, G.M. / Switchenko, A.C. / Primus, J.P. -- TETRAHYDROBIOPTERIN BIOSYNTHESIS. STUDIES ON THE REACTION OF DIHYDRONEOPTERIN TRIPHOSPHATE IN THE PRESENCE OF PHOSPHATE-ELIMINATING ENZYME FROM HUMAN LIVER / Curtius, H.-Ch. / Leimbacher, W. / Niederwieser, A. / Ghisla, Sandro -- BIOSYNTHESIS OF TETRAHYDROBIOPTERIN: INCORPORATION OF LABEL FROM REDUCED PYRIDINE NUCLEOTIDE DURING FORMATION FROM DIHYDRONEOPTERIN TRIPHOSPHATE / Ghisla, Sandro / Curtius, Hans-Christoph / Heintel, Dorothee / Küster, Thomas / Leimbacher, Walter / Niederwieser, Alois -- TETRAHYDROBIOPTERIN BIOSYNTHESIS IN MAN / Heintel, Dorothee / Leimbacher, Walter / Redweik, Udo / Blau, Nenad / Niederwieser, Alois / Curtius, Hans-Christoph / Ghisla, Sandro -- PHOSPHORYLATION OF UNPROTECTED D-NEOPTERIN / Zagalak, B. / Neuheiser, F. / Curtius, H.-Ch. -- MEASUREMENT OF PHOSPHATE-ELIMINATING ENZYME (PEE) ACTIVITY IN LIVER BIOPSIES / Niederwieser, A. / Leimbacher, W. / Curtius, H.-Ch. -- INHIBITION OF THE TETRAHYDROPTERIN PATHWAY FOR BIOPTERIN COFACTOR BIOSYNTHESIS BY N-ACETYLSEROTONIN IN CELL CULTURES AND IN ENZYME PREPARATIONS AND STUDIES ON THE MECHANISM OF TETRAHYDROPTERIN FORMATION / Smith, Gary K. / Duch, David S. / Nichol, Charles A. -- ACTH STIMULATION OF TETRAHYDROBIOPTERIN BIOSYNTHESIS AND STEROIDOGENESIS IN ADRENAL CORTICAL TUMOR CELLS IN CULTURE / Duch, David S. / Woolf, Jeffrey H. / Edelstein, Mark P. / Viveros, O. Humberto / Abou-Donia, Martha M. / Nichol, Charles A. -- ENDOCRINE AND METABOLIC REGULATION OF GTP-CYCLOHYDROLASE ACTIVITY AND TETRAHYDROBIOPTERIN LEVELS IN RAT LIVER / Abou-Donia, Martha M. / Daniels, Alejandro J. / Diliberto, Emanuel / Nichol, Charles A. / Viveros, O. Humberto -- TETRAHYDROBIOPTERIN SYNTHESIS AND THE ROLE OF THE COFACTOR IN THE REGULATION OF TYROSINE HYDROXYLATION IN ADRENOMEDULLARY CHROMAFFIN CELLS / Abou-Donia, Martha M. / Zimmerman, Thomas P. / Nichol, Charles A. / Viveros, O. Humberto -- BIOPTERIN METABOLISM IN HEPATOMA CELLS / Dhondt, Jean-Louis / Cotton, Richard G.H. / Fowler, Kerry -- HIGH BIOPTERIN CONCENTRATION IN NUCLEAR FRACTIONS OF REGIONAL RAT-BRAIN PREPARATIONS / Knapp, S. / Merwin, M. -- 3. TETRAHYDROBIOPTERIN DEFICIENCIES, DIAGNOSIS AND THERAPY -- TRANSIENT NEONATAL HYPERPHENYLALANINEMIA DUE TO DEFECTIVE SYNTHESIS OF 7,8-DIHYDROBIOPTERIN / Okano, Y. / Shintuku, H. / Sawada, Y. / Isshiki, G. / Hase, Y. / Tsuruhara, T. / Oura, T. / Takahashi, S. / Kodama, Y. -- TETRAHYDROBIOPTERIN ANALOGUES AND THEIR ABILITY TO ENTER THE RAT STRIATUM AFTER PERIPHERAL ADMINISTRATION / Levine, Robert A. / Zoephel, Gerd Peter / Niederwieser, Alois / Curtius, Hans-Christoph / Traub, Herman / Pfleiderer, Wolfgang -- 4. PTERIDINES IN IMMUNOLOGY -- IMMUNE RESPONSE- ASSOCIATED NEOPTERIN RELEASE: AN OVERVIEW / Huber, Christoph / Troppmair, Jacob -- NEOPTERIN ESTIMATION an in vivo test measuring the cell mediated immune status / Fuch, Dietmar / Hausen, Arno / Lutz, Hermann / Reibnegger, Gilbert / Werner, Ernst R. / Wächter, Helmut -- NEOPTERIN IN SERUM OF MAMMALS? / Rokos, H. / Bienhaus, G. / Kunze, R. -- The Relations of HTLV-III antibodies to Neopterin and Beta-2- Microglobulin in the Serum of Patients with AIDS or Persons at Risk / Goebel, F.-D. / Erfle, V. / Piechowiak, H. / Hien, P. / Schloz, H. / Hehlmann, R. -- INCREASE IN SERUM NEOPTERIN LEVELS IN PATIENTS RECEIVING RECOMBINANT INTE RLE UK IN-2 AND RECOMBINANT INTERFERON CC A / Kern, P. / Dietrich, M. -- CLINICAL RESOLVEMENT OF MALARIA INFECTION PARALLELS DECREASE OF HIGHLY ELEVATED SERUM NEOPTERIN LEVEL / Kern, P. / Horstmann, R.D. / Dietrich, M. -- ACCUMULATION AND RELEASE OF PTERIDINES DURING STIMULATION OF HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PARTICIPATION IN THE CONTROL OF ANTIGEN INDUCED T-CELL EXPANSION / Ziegler, I. -- INTRACELLULAR CHANGES IN PTERIN RELEASING PERIPHERAL BLOOD MONONUCLEAR CELLS AFTER STIMULATION WITH INTERFERON-GAMMA / Troppmair, J. / Lang, A. / Huber, Ch. / Schoedon, G. / Niederwieser, A. / Adolf, G. -- METABOLISM OF PTERINS IN HUMAN PERIPHERAL BLOOD MONONUCLEAR / Schoedon, Gabriele / Niederwieser, Alois / Troppmair, Jakob / Huber, Christoph -- URINARY NEOPTERIN EXCRETION IN THE FOLLOW UP OF BONE MARROW TRANSPLANT RECIPIENTS / Niederwieser, D. / Huber, Ch. / Troppmair, J. / Gratwohl, A. / Würsch, A. / Speck, B. / Margreiter, R. / Adolf, G. / Fuchs, D. / Hausen, A. / Reibnegger, G. / Wächter, H. -- PTERIDINES IN BONE MARROW TRANSPLANTATION: THE PROBLEM OF PHARMACOLOGICAL. INTERACTIONS / Fink, M. / Ziegler, I. / Rokos, H. -- SERUM NEOPTERIN DETERMINATION IN BONE MARROW TRANSPLANTATION IN CHILDHOOD / Lang, H.R.M. / Schmiedmeier, W. / J.F.K., Huber -- RADIOIMMUNOLOGICAL DETERMINATION OF SERUM NEOPTERIN IN PATIENTS FOLLOWING BONE MARROW TRANSPLANTATION - FIRST RESULTS / Kalhs, P. / Fischer, M. / Dudczak, R. / Hinterberger, W. / Lechner, K. / Schwarzinger, I. / Frischauf, H. / Deutsch, E. / Volc-Platzer, B. -- PTERIDINES IN URINE AND SERUM IN KIDNEY ALLOGRAFT RECIPIENTS / Dhondt, J.L. / Hayte, J.M. / Noël, C. -- RELATION OF NEOPTERIN TO INTERFERON GAMMA SERUM LEVELS IN PATIENTS WITH KIDNEY TRANSPLANTS / Woloszczuk, W. / Kovarik, J. / Schwarz, M. / Pohanka, E. / Mayer, G. -- SERUM NEOPTERIN IN PATIENTS WITH KIDNEY ALLOGRAFTS: CLINICAL IMPLICATIONS / Schwarz, M. / Pohanka, E. / Mayer, G. / Kovarik, J. / Woloszczuk, W. -- URINARY NEOPTERIN IN ACUTE AND CHRONIC LIVER DISEASES / Farci, A.M.G. / Laconi, R. / Cabras, F. / Loviselli, A. / Cappai, G. / Balestrieri, A. / Garau, V.L. / Tocco, M. / Casula, D. -- URINARY NEOPTERIN EXCRETION AS AN ACTIVITY PARAMETER IN CROHN'S DISEASE / Prior, Ch. / Judmaier, G. / Fuchs, D. / Hausen, A. / Reibnegger, G. / Werner, E. R. / Wächter, H. / Bollbach, R. / Rotthauwe, H. W. -- INTERFERON-GAMMA-INDUCED IN VITRO-EXCRETION OF NEOPTERIN AND 3-HYDROXYANTHRANILIC ACID BY HUMAN MACROPHAGES / Werner, Ernst R. / Fuchs, Dietmar / Hausen, Arno / Lutz, Hermann / Reibnegger, Gilbert / Wächter, Helmut / Huber, Christoph / Troppmair, Jakob -- 5. PTERIDINES IN CANCER AND OTHER DISEASES -- INTERPRETATION OF THE VARIABLE NEOPTERIN EXCRETION IN PATIENTS WITH DIFFERENT TUMOR TYPES - A HYPOTHESIS / Hausen, Arno / Fuchs, Dietmar / Lutz, Hermann / Reibnegger, Gilbert / Werner, Ernst R. / Wachter, Helmut -- URINARY NEOPTERIN IN CHILDREN WITH MALIGNANT NEOPLASM / Shintaku, Haruo / Yamato, Kazumi / Sawada, Yoshitomo / Miyata, Yusuke / Isshiki, Gen / Hase, Yutaka / Tsuruhara, Tsuneo / Oura, Toshiaki / Tanaka, Mitsuru / Nakamura, Shiro -- THE CLINICAL RELEVANCE OF THE NEOPTERIN-DETERMINATION IN PATIENTS WITH CERVICAL AND OVARIAN CANCER / Hetzel, Heinz / Bichler, Alfred / Fuith, Lothar C. / Fuchs, Dietmar / Hausen, Arno / Lutz, Hernann / Reibnegger, Gilbert / Werner, Ernst R. / Wächter, Helmut -- DETERMINATION OF SERUM NEOPTERIN IN PATIENTS WITH ACUTE LEUKEMIA AND MALIGNANT LYMPHOMAS / Lang, H.R.M. / Linkesch, W. / Huber, J.F.K. -- NEOPTERIN - A MARKER OF THE CELLULAR IMMUNE RESPONSE IN PATIENTS WITH LUNG CANCER / Conrad, F. / Salzer, G.M. / Fuchs, D. / Hausen, A. / Reibnegger, G. / Wachter, H. -- Neopterin levels in different human tumors under treatment with antitumoral peptides (Factor AF2), course, response rate, prognosis / Voelter, W. / Ebner, B. / Bauer, H. / Róhrer, H. / Porcher, H. / Stiefel, Th. -- PTERIDINES IN PLASMA AND IN BLOOD CELLS FROM LEUKAEMIA PATIENTS / Andondonskaja-Renz, B. / Zeitler, H.-J. -- PTERIDINES FROM BONE MARROW AND BODY FLUIDS FROM HEALTHY DONORS AND FROM DIFFERENT PATIENTS / Zeitler, H.-J. / Andondonskaja-Renz, B. -- PTERIDINE LEVELS IN PATIENTS WITH AIDS (ACQUIRED IMMUNODEFICIENCY SYNDROME) AND WITH KAPOSI'S SARCOMA / Zeitler, H.-J. / Andondonskaja-Renz, B. -- Comparative Studies on Urinary Neopterin Excretion and other Laboratory Parameters / Reibnegger, G. / Fuchs, D. / Hausen, A. / Lutz, H. / Werner, E.R. / Wächter, H. -- 6. MISCELLANEOUS -- EFFECT OF PTERIDINES ON HYDROXY-INDOLE-O-METHYLTRANSFERASE HIOMT) / Cremer-Bartels, G. -- PTERIDINE VALUES IN CEREBROSPINAL FLUID IN SICK CHILDREN / Sawada, Yoshitomo / Shintaku, Haruo / Isshiki, Gen / Hase, Yutaka / Tsuruhara, Tsuneo / Oura, Toshiaki -- EXOGENOUS FACTORS INFLUENCING THE EXCRCETION OF NEOPTERIN / Wildgrube, H.J. / Stockhausen, H. / Stockhausen, W. -- NEONATAL MEGALOBLASTIC ANEMIA CAUSED BY AN INHERITED DEFECT IN THE METHIONINE SYNTHETASE REACTION IN VIVO / Cooper, Bernard A. / Rosenblatt, David -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter