Advances in Research on Neurodegeneration

Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia.- Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model.- Progressive neurodegeneration in Drosophila: a model system.- Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease.- What have we learnt from cDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson's disease?.- Animal models of Parkinson's disease in rodents induced by toxins: an update.- General aspects of neurodegeneration.- The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour.- New concepts and tools in imaging for the study of neurodegenerative disease.- Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson's disease.- The role of acetylcholine and dopamine in dementia and psychosis in Parkinson's disease.- Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-ß superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning.- Gene therapy for Parkinson's disease.- Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson's disease.