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| Artikel-Nr.: 5667A-9783384280077 Herst.-Nr.: 9783384280077 EAN/GTIN: 9783384280077 |
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![](/p.gif) | Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a fibril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disulfide bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, fibrin and integrins facilitating matrix organization and cell-matrix interactions [18]. For example, fibronectin serves as a template for proper collagen fibrillogenesis by forming a fibril network engaged by cell surface integrins [16]. Cellular traction force causes FN to be stretched several times over its resting length [18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior [18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis Weitere Informationen: ![](/p.gif) | ![](/p.gif) | Author: | Mackil | Verlag: | tredition | Sprache: | eng |
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![](/p.gif) | Weitere Suchbegriffe: gesundheitsratgeber - englischsprachig, Minimally Invasive; Biomarkers; Disease; Vascular surgery; for comparison; patient selection; risk stratification; Clinical Trials, Abdominal Aortic, Minimally Invasive, Therapies, Risk Stratification, Clinical Trials, Biomarkers, Patient Selection, Disease, Vascular Surgery, for comparison |
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