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Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate


Menge:  Stück  
Produktinformationen
cover
cover
Artikel-Nr.:
     5667A-9783642627675
Hersteller:
     Springer Verlag
Herst.-Nr.:
     9783642627675
EAN/GTIN:
     9783642627675
Suchbegriffe:
Medizinbücher
Medizinbücher - englischsprachig
Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.
Weitere Informationen:
Author:
A. Israel; B. de Strooper; F. Checler; Y. Christen
Verlag:
Springer Berlin
Sprache:
eng
Weitere Suchbegriffe: Alzheimer's disease; Nervous System; Proteolysis; neurons; nicastrin; presenilin; ubiquitin-proteasome pathway, ALzheimer's Disease, Nervous System, Proteolysis, neurons, nicastrin, presenilin, ubiquitin-proteasome pathway
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