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| Artikel-Nr.: 5667A-9783736999138 Herst.-Nr.: 9783736999138 EAN/GTIN: 9783736999138 |
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![](/p.gif) | Beschreibung The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, ?-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for ?-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose. Weitere Informationen: ![](/p.gif) | ![](/p.gif) | Author: | Jonathan Thomas Fabarius | Verlag: | Cuvillier Verlag | Sprache: | eng |
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![](/p.gif) | Weitere Suchbegriffe: Biowissenschaften, Life Sciences, Biologie / Mikrobiologie, Mikrobiologie - Mikroorganismus, Virologie, Virus - Virologie, bacterium Basfia; bio-succinic acid; carbon-three chemicals, bacterium Basfia, carbon-three chemicals, bio-succinic acid |
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