NMDA Antagonists as Potential Analgesic Drugs

Pharmacology and electrophysiology of excitatory amino acid receptors.- Distribution of NMDA receptors in brain and spinal cord.- Spinal nociceptive processing: NMDA receptors and modulation by neuropeptides.- The NMDA receptor, pain and central sensitization.- Some pharmacological aspects of NMDA-mediated nociceptive transmission in the rat spinal cord as revealed by c-fos immunocytochemistry.- Interaction of NMDA and other neurotransmitter receptor systems in modulation of nociception.- Behavioural studies on the potential of NMDA receptor antagonists as analgesics.- Clinically available glutamate receptor antagonists in neuropathic pain states.- Future prospects for improved analgesic therapy.