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| Artikel-Nr.: 5667A-9783319380674 Herst.-Nr.: 9783319380674 EAN/GTIN: 9783319380674 |
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| This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more. Weitere Informationen: | | Author: | Benjamin Bonavida; Salem Chouaib | Verlag: | Springer International Publishing | Sprache: | eng |
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| Weitere Suchbegriffe: HDACinhibitors; Proteasomeinhibitors; apoptosis; cytotoxictlymphocytes; drug-resistantcancercells; epitopes; antibacterialdrugresistance, HDAC inhibitors, Proteasome inhibitors, apoptosis, cytotoxic t lymphocytes, drug-resistant cancer cells, epitopes, antibacterial drug resistance |
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